An activation key is an encoded bit string that defines the list of features to enable, how long the key would stay valid upon activation, and the specific serial number of a Cisco ASA device. these findings suggest that areas where oss is generated, such as in aortic stenosis, are more likely to display endomt, a hallmark of atherosclerosis 29 and fibrosis 17. our data shows that platelet releasates subjected to oss can induce tgf- signaling in endothelial cells for p-smad2 and genes responsible for the endomt process, a hallmark of pathologic organ fibrosis 28. these results suggest further studies should determine whether oss-induced tgf-1 activation around valve leaflets contributes to as progression. endomt is a phenomenon induced by tgf-1 signaling 17, and we found platelets are physically attached with valvular endothelial cells inducing mesenchymal transition 19.

we recently showed that shear-activated platelet tgf-1 directly contributes to aortic stenosis (as) progression in a robust mouse model 19. only the currently active licenses for each feature continue the time countdown you can stop the timer by manually deactivating a key or installing a different time-based license for the same feature.Įndomt is a hallmark of pathologic organ fibrosis 17 and its process has been implicated in atherosclerosis 29 and myocardial fibrosis 31 and formation of cardiac valves 32 and coronary arteries 33. other time-based keys remain installed but inactive until needed. thus, several time-based keys can stay active on the asa as long as they enable different features. even though you can apply multiple time-based activation keys on the same cisco asa concurrently, only one license remains active for any particular feature at any given time. all premium features can be activated by either permanent or time-based keys, with the exception of botnet traffic filter, which is only available via a time-based license. In addition to the permanent activation key, you can install one or more time-based keys to enable certain features for a limited period of time. when you apply a new permanent activation key, the previous permanent activation key is terminated and disabled. after the permanent activation key expires, you can apply a new permanent activation key to activate a new feature set. in most situations, you will want to use the permanent activation key, which is not time-limited. After a time-based activation key expires, you can still use a permanent activation key to enable the same feature set.

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